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Red Blood Cell Size Vs White Blood Cell Size

Red Blood Cell Size Vs White Blood Cell Size


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I have just found out that white blood cells are larger than red blood cells and now I'm confused due to something I learnt in class. Basically, I was taught that there were spaces between the endothelial cells lining the capillary and these spaces allow white blood cells to escape and enter infected tissues to help clear out the infection. Why don't the red blood cells escape then if they are smaller than white blood cells they should fit through the spaces as well right?


  1. there are several types of white blood cells (at least 4) and they vary greatly in size from type to type.

  2. white blood cells are not rigid, they can squeeze through very small openings. it always buts me in mind of watching a octopus squeeze into a bottle.


Difference Between Human and Frog Blood Cells

Human and frog are two kinds of animals with different evolutionary levels. Humans are mammals while frogs are amphibians. The three main types of blood cells are red blood cells, white blood cells, and platelets. The main difference between human blood cells and frog blood cells is that human red blood cells lack nuclei whereas frog blood cells consist of nuclei. The white blood cells of both human and frog are similar to each other by means of morphology as well as function.

Key Areas Covered

Key Terms: Agranulocytes, Frog Blood Cells, Granulocytes, Human Blood Cells, Red Blood Cells, Red Cell Nuclei, Platelets


2. Granular myeloid white blood cells, also called granulocytes, contain cytoplasmic granules and lobed nuclei.

Granules are particles in a cell’s cytoplasm that show up as small spots when the cell is examined through a microscope. They are often secretory vessels.

The different types of granular myeloid white blood cells—neutrophils, basophils, and eosinophils—are named based on the type of stain that makes their granules most visible. Each type of granular myeloid white blood cell has granules with different chemical contents that help these cells respond to different types of pathogens.


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What is the relationship between red blood cells and white blood cells? anon292683 September 21, 2012

I have been diagnosed with rheumatoid arthritis. My doctor put me on a yellow tablet which is helping the pain. The only thing is I have to get bloodwork done every month now. It has something to do with the red and white blood cells. I do hope the doctor does not take me off this medication as it helps the pain. giddion September 14, 2012

@wavy58 – I got sick so many times last year and had to take so many antibiotics that my white blood cell count was up and down like a roller coaster! I would feel like I was at death's door, but after the antibiotics kicked in to help out my white blood cells, I would suddenly feel so much better.

White blood cells just look intimidating. I wonder if bacteria panic at all when they see these spiky looking cells rolling toward them!

Red blood cells look so much more smooth and gentle. They don't look like they could cause any damage at all. orangey03 September 13, 2012

Did you know that dehydration can raise your red blood cell count? My cousin had to be hospitalized a few months ago because she was extremely dehydrated, and the doctor told her that her red blood cell count was high.

He said that when a person becomes dehydrated, their blood does not have as much fluid in it. So, it makes sense that the blood cells make up more of its volume.

She had to be pumped full of fluids intravenously, and this got everything back to normal. It is amazing what all dehydration can cause, though. Kristee September 12, 2012

I have had problems with stress for years. It can cause many things to go wrong in your body. I recently discovered that extreme stress can actually raise your white blood cell count!

My blood pressure goes up when I'm really stressed, and this causes my white cell count to rise. My doctor told me that having a high WBC count for a long time could lead to an autoimmune disease, so she put me on anti-anxiety medication. wavy58 September 12, 2012

I've heard that antibiotics can decrease your white blood cell count. I don't imagine they have any effect on red blood cells, though.

Since white blood cells fight infections and you would be taking antibiotics to help your body fight the infection, I can see why these drugs would lower the white blood cell count. Antibiotics take a load off the cells, so they can take a break from sending out soldiers! anon271907 May 29, 2012

What is the difference between cancer cells and healthy cells?

why are red blood cells so much more likely to lyse when distilled water is added to a solution than white blood cells would be? anon210955 September 1, 2011

I had a total knee replacement eight months ago and it has been the worst experience of my life. I still can not walk or bend knee as usual and I am still in a pain. I was given a CBC test to see if I had an infection in my knee. I was wondering if I had a UTI or bacterial infection would make my test results come back elevated. I have asked two different doctors. One said it could make it come back elevated and one said only a kidney infection could. Does anyone know the truth? anon175055 May 11, 2011

I am having a test on my blood. They want to separate the red from white. I had a total knee replacement year ago and the knee is still swollen and cannot bend the knee. what has this to do with my knee? anon103043 August 10, 2010

my white cells are 5 and my red cells are 4. what does this mean? anon67588 yesterday

this could be anemia which can lead to leukemia.

What would cause white blood cells and red blood cells to be low? anon47452 October 5, 2009

do the red and white blood cells produce minerals? anon31622 May 8, 2009

What is the relationship between white and red blood cells?

why do we separate erythrocyte ghost cell for cancer? anon6120 December 17, 2007

What is the difference between hemoglobin and red blood cell? What the normal range from male and female?

my mother is tired all the time. The doctor said her white cell count goes up and down. what can this be?


Peripheral Blood Lab

Blood provides a mechanism by which nutrients, gases, and wastes can be transported throughout the body. It consists of a number of cells suspended in a fluid medium known as plasma. The cells of the blood consist of erythrocytes, platelets, and leukocytes or white blood cells. Erythrocytes are responsible for transporting gases,

The cells of the blood are important because they are a readily accessible population whose morphology, biochemistry, and ecology may give indications of a patient's general state or clues to the diagnosis of disease. For this reason, the complete blood count (CBC) and the differential white cell count are routinely used in clinical medicine. It is very important to be able to recognize normal blood cells and to distinguish pathological cells from the normal variants.

The identification of blood cells is based primarily on observations of the presence or absence of a nucleus and cytoplasmic granules. Other helpful features are cell size, nuclear size and shape, chromatin appearance, and cytoplasmic staining. The chart at the end of this section explains what to look for in the effort to identify the component cells of a blood smear.

Erythrocytes

Erythrocytes, or red blood cells, are by far the predominant cell type in the blood smear. They appear as biconcave discs of uniform shape and size (7.2 microns) that lack organelles and granules. Red blood cells have a characteristic pink appearance due to their high content of hemoglobin. The central pale area of each red blood cell is due to the concavity of the disc. Also visible in this slide are several platelets, which play a crucial role in the blood clotting cascade.

Neutrophils

Neutrophils are by far the most numerous of the leukocytes. They are characterized by a nucleus that is segmented into three to five lobes that are joined by slender strands. The cytoplasm of neutrophils stains a pale pink. Its primary (larger) granules contain acid hydrolases and cationic proteins, and its secondary (smaller) granules contain a variety of antimicrobial substances used to destroy bacteria that they phagocytose during the acute inflammatory response.

Eosinophils

Eosinophils are larger than neutrophils and are distinguished by bilobed nucleus and large red or orange granules of uniform size. These granules contain major basic protein, which is released to kill organisms too large to phagocytose, such as parasites and helminthes (worms). Eosinophils make up between 1 and 3% of the total white blood cells in the human blood.

Basophils

Basophils are intermediate in size between neutrophils and eosinophils and have simple or bilobed nuclei. They contain many coarse purple granules that can vary in size or shape. These granules contain histamine, which is released to cause a vasoactive response in hypersensitivy reactions, and heparin, which is an anticoagulant. Basophils are not phagocytic.

Lymphocytes

Lymphocytes can appear either small or large. The small lymphocyte is about the same size as an erythrocyte and contains a dark nucleus with a thin rim of surrounding cytoplasm. Lymphocytes do not contain visible granules. Small lymphocytes are inactive. Large lymphocytes (10 - 15 microns) contain more cytoplasm than small lymphocytes, and the cytoplasm remains basophilic. Large lymphocytes are active B or T cells. It is not possible to distinguish B- and T-lymphocytes at this level of magnification.

Monocytes

Monocytes are larger than lymphocytes and granulocytes and contain nuclei that often contain an indentation on one side. The cytoplasm contains small granules with lysosomal enzymes and peroxidase. Monocytes are phagocytic cells that are important in the inflammatory response.


What is the Normal Size of Red Blood Cells? (with pictures)

The size of red blood cells usually falls within a range of 6 to 8 micrometers in random blood samples that have been analyzed by laboratory testing. Mature forms of the red blood cells (RBCs) are called erythrocytes, which constitute around 40 to 45% of human red blood cells. Immature forms of red blood cells are termed reticulocytes, and these usually account for only about 1 to 2% of the red blood cells.

Erythrocytes are larger red blood cells that have a shape similar to a round hard candy with a hole in the center, having a structure that is called “biconcave.” The structure is naturally flexible and bendable, however, in order to provide easier passage through the blood vessels going around the body. Their shape also allows these cells to absorb greater amounts of oxygen during their circulation throughout the blood, since it provides a greater surface area for absorption. This is important since one of the functions of erythrocytes is to provide a sufficient oxygen exchange for body tissues and organs.

Several lab tests can be used to measure the characteristics of an average red blood cell. A mean corpuscular volume (MCV) test measures the average size of the cell. A mean corpuscular hemoglobin (MCH) test measures the cell’s content of hemoglobin — a red protein substance that carries oxygen within the cell. A mean corpuscular hemoglobin concentration (MCHC) test measures the ratio of hemoglobin to cell size.

These tests are important in that they can show the presence of anemia — a condition that arises when the hemoglobin content in regular red blood cells is too low to provide the body with sufficient oxygen. This condition is defined according the size of red blood cells and the amount of hemoglobin the cells carry. Red blood cell indices on the lab tests help to determine if anemia is present, by establishing normal hemoglobin ranges for males and females, generally within a range of 12 to 17 grams per deciliter.

The size of red blood cells depends largely upon their maturity. RBCs are produced on a continual basis in the body within the bone marrow, such as the large bone of the femur. Once an erythrocyte is created, it grows to maturity in approximately 7 days, and each cell lives approximately 120 days. Moreover, a mammalian erythrocyte is distinguished from other vertebrate species — those having a vertebra, or spine — by the fact that mammalian erythrocytes do not have a cell nucleus, a center containing genetic material. All other vertebrate erythrocytes retain the capacity that human cells lose once they develop to maturity.


Red blood cells, large and small!

We can learn a lot about animals by looking at their cells, and red blood cells are no exception. These specialized cells—found in vertebrates and six other groups of animals—travel in blood vessels to transport oxygen and carbon dioxide between the lungs (or gills) and the rest of the body. Red blood cells get their color from heme, an iron-containing molecule that transports oxygen.

Red blood cells were first studied in the 1600s, soon after the development of modern light microscopes by Dutch scientists. As microscope technology improved, scientists began to measure the shapes and sizes of red blood cells and to notice differences between cells from different animals.

In 1875, George Gulliver summarized this research by drawing red blood cells from over 80 species of vertebrates to relative scale (see picture). This drawing highlights the similarities and differences in red blood cell structure, size and shape across species.

Like most animal cells, red blood cells from fish, amphibians, reptiles and birds all contain DNA in nuclei, represented by shaded ovals in Gulliver’s drawing. By contrast, the red blood cells of mammals lack nuclei and other internal structures found in most animal cells. This simplification allows mammal red blood cells to carry more gas-transporting proteins and to squeeze through smaller blood vessels.

The red blood cells that Gulliver drew range in diameter from the tiny cells of the mouse deer (2 micrometers) to the giant cells of Amphiuma salamanders (66 micrometers). In red blood cells that have nuclei, the amount of DNA sets a lower limit on cell size. Amphibians such as Amphiuma salamanders have up to 25 times more DNA than humans, leading to giant red blood cells. Animals with higher energy needs like mammals and birds have smaller red blood cells, which can exchange gas and travel through blood vessels more efficiently.

The presence of a nucleus makes most fish, amphibian, reptile and bird red blood cells oval-shaped. Without nuclei, mammal red blood cells adopt unique shapes. In many species—including humans—red blood cells have an inner tube-like shape that increases gas exchange efficiency. Mouse deer cells are spherical to minimize diameter while camels and their relatives have oval cells that may help them survive drought conditions.

Today, scientists continue to ask questions about red blood cells from humans and other animals. How does red blood cell shape and size relate to animal anatomy and energy needs? How do red blood cells change as we grow older or when we get sick? What proteins control red blood cell shape and size? Answering these questions can help us understand how humans evolved and how to treat human diseases.

Glossary

This is a list of classification terms used by Gulliver. Since 1875, new findings on the relationships between animals have led scientists to alter some of these classifications.

Vertebrata ahyrnæmata: mammals (red blood cells lack nuclei)

Vertebrata pyrenæmata: non-mammal vertebrates (red blood cells have nuclei)


Difference Between White and Red Blood Cells

The human body is composed of multitudes of very important cells. In this connection there are two very importance blood cells that were given very trivial names and these are the white blood cells and the red blood cells. So how do they differ?

In terms of function, the two blood cells have very different roles in the body. Foremost, the red blood cells (RBCs) ensure that sufficient oxygen is supplied throughout the entire body. They have the pigment called hemoglobin ‘“ the oxygen carrying component of the blood.

Supplying adequate oxygenation to the system is equivalent to sufficient amounts of energy. Therefore, when somebody is suffering from anemia (low RBC count) then he or she will most likely appear weak and unenergetic. The opposite (abnormally high RBC count) is also bad for one’s health as it may induce kidney diseases and even fibrosis of the organs in the pulmonary (respiratory) system like the lungs. They will also have a thicker blood viscosity making them more prone to heart diseases and hypertension.

Aside from its function of supplying oxygen to the body, it also serves as a medium to get rid of some waste materials. Carbon dioxide is one of them. This gas is picked up by the RBCs for its expulsion from the system through a series of metabolic processes.

RBCs are also known in their alternative medical term as erythrocytes. Because of their presence in the blood, they contribute to the its natural red color. White blood cells, on the contrary, are otherwise called leukocytes.

WBCs fend off foreign invaders as they are the primary agents responsible for the body’s natural immune defense. They fight almost any pathological agent like bacteria, parasites and also allergens. T-cell is a specific type of WBC that is compromised in individuals who have contracted HIV. Like RBCs, an excess of WBCs is also bad for the health. In fact, this condition is known as leukemia, popularly regarded as cancer of the blood. There are also some medications that can lead to the opposite (decrease in WBCs). Some psychiatric drugs like Clozapine can lead to such and in turn makes the person an easy target for most diseases.

RBCs are more in number ‘“ about 5 million in every mm3 of blood. This is just too much compared to WBCs that only sum from 3,000 to 7,000 per mm3 of blood. Their lifespan also vary since RBCs tend to live longer (120 days) compared to WBCs (4 days the most).

Structure wise, RBCs don’t have any nuclei compared to white blood cells (WBC). Their shape can change most especially when they become squeezed. WBCs’ shape depends on their specific function.

1. RBCs are useful for the transportation of oxygen and carbon dioxide within the body while WBCs are useful in their role as the body’s natural defenders.


The immune system, as well as many processes of the human body at the cellular level, can be hard to understand since until recently the technology was unavailable to really SEE what’s happening. Blood cells, bacteria, viruses, and nano particles (like those in colloidal silver) are all very tiny…but are still relatively different in size!

The Immune System In Action! Here’s a video of a white blood cell chasing down bacteria (specifically: Staphylococcus aureus):



Notice how much larger the white blood cell is to the bacteria! To better understand the relative size difference, you can go to this site, and compare a dust mite (relatively large), to a white blood cell (smaller), to red blood cells (smaller), to bacteria (smaller) to viruses (tiny)!

Rhinovirus, the smallest pahtogen in the site’s example, measures about 20 nanometers in diameter. The particles in true colloidal silvers are about .65 nanometers in diameter!

To further understand how small a nanometer is: on average, fingernails grow 1 nanometer per second. Or, a nanometer is about 1 million times smaller than an ant!

When you understand how small silver nanoparticles are, it’s easier to understand why tests have shown that they easily exit the body (sutdy—download). It’s also understandable why some people are concerned about nano particles (including nano silver) and human health and the environment: they’re so small, it’s hard (& expensive) to have a complete understanding of what’s happening!

So far tests haven’t found negative effects of nano silver (including argyria), but testing will continue as nano silver enters the market in food and household products, and replaces chemicals in antimicrobial roles (replacing pesticides, etc.!).

What questions do you have about the immune system and its different cells? Would you like to see more videos like this? Leave your feedback below!


Materials and methods

On the basis of the raw RBC microscopy image data from SCD patients following cell density fractionation [21] as shown in S1 Appendix, our automatic, high-throughput RBC classification assay consists of four main steps for the RBC-dCNN training: 1) Hierarchical RBC patch extraction, 2) Size-invariant RBC patch normalization, 3) RBC pattern classification based on deep CNN, and 4) Automated RBC shape factor calculation. A detailed overall training flowchart is shown in Fig 1. Each step of the algorithm is described below.


Watch the video: White blood cell vs bacteria with Linkin Park background music (May 2022).